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ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0001515673 rare:PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0001515673 rare:PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0001515673 rare:LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember ecd:NonPeoNeoMember 2024-01-01 2024-12-31 0001515673 rare:LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember ecd:NonPeoNeoMember 2023-01-01 2023-12-31 0001515673 rare:LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember ecd:NonPeoNeoMember 2022-01-01 2022-12-31 0001515673 rare:LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember ecd:NonPeoNeoMember 2021-01-01 2021-12-31 0001515673 rare:LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember ecd:NonPeoNeoMember 2020-01-01 2020-12-31 0001515673 1 2024-01-01 2024-12-31 0001515673 2 2024-01-01 2024-12-31 0001515673 3 2024-01-01 2024-12-31 0001515673 4 2024-01-01 2024-12-31 iso4217:USD shares iso4217:USD shares pure false 0001515673 DEF 14A ULTRAGENYX PHARMACEUTICAL INC. true Generally, the Compensation Committee grants annual equity awards, including stock options, on March 1 of each year following the filing of our Annual Report on Form 10-K and grants new hire equity awards, including stock options, on the 16th of each month following the individual’s start date. The Compensation Committee may also grant equity awards at other times during the year, such as in connection with special retention awards, performance recognition, or in the event of a significant change in job responsibilities. Under the 2014 Employee Stock Purchase Plan, eligible employees may purchase shares at a discount, with purchase dates generally on April 30 and October 31 of each year, using payroll deductions accumulated during the prior six-month period. The Compensation Committee did not take material nonpublic information into account when determining the timing and terms of equity awards, including stock options, during 2024, and we did not time the disclosure of material nonpublic information for the purpose of affecting the value of executive compensation. During 2024, no stock options were granted to the named executive officers in the period beginning four business days before and ending one business day after the filing or furnishing of any Form 10-Q, Form 10-K or Form 8-K that disclosed material nonpublic information. Generally, the Compensation Committee grants annual equity awards, including stock options, on March 1 of each year following the filing of our Annual Report on Form 10-K and grants new hire equity awards, including stock options, on the 16th of each month following the individual’s start date. The Compensation Committee may also grant equity awards at other times during the year, such as in connection with special retention awards, performance recognition, or in the event of a significant change in job responsibilities. Under the 2014 Employee Stock Purchase Plan, eligible employees may purchase shares at a discount, with purchase dates generally on April 30 and October 31 of each year, using payroll deductions accumulated during the prior six-month period. true The Compensation Committee did not take material nonpublic information into account when determining the timing and terms of equity awards, including stock options, during 2024, and we did not time the disclosure of material nonpublic information for the purpose of affecting the value of executive compensation. false false <div id="xdx_805_eecd--PvpTableTextBlock_z3O9k7jFzz0i"></div> <h1 style="font: 20pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; color: #7CBD3F">Pay versus Performance</h1> As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, we are providing the following information about the relationship between Compensation Actually Paid (CAP) and certain financial performance of the Company. For further information concerning the Company’s pay for performance philosophy and how the Company’s aligns executive compensation with the Company’s performance, refer to “Executive Compensation – Compensation Discussion and Analysis.” <table cellpadding="0" cellspacing="0" id="xdx_305_zeZOk7F7n9Y5" style="font: 9pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="line-height: 1pt"> <td> </td> <td> </td> <td> </td> <td id="xdx_48A_eecd--PeoTotalCompAmt_zs1bCf4oAMUh"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_48E_eecd--PeoActuallyPaidCompAmt_z3vckMEurLN1"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_488_eecd--NonPeoNeoAvgTotalCompAmt_zzuLQdxkJbUa"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_483_eecd--NonPeoNeoAvgCompActuallyPaidAmt_zGYTD0aV7wF7"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_48F_eecd--TotalShareholderRtnAmt_zXUMm2KpYNVl"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_488_eecd--PeerGroupTotalShareholderRtnAmt_zpX8kDX53hP9"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_482_eus-gaap--NetIncomeLoss_pdn3_zAROLmUTe1Yb"> </td> <td> </td> <td> </td> <td> </td> <td id="xdx_481_eecd--CoSelectedMeasureAmt_pdn3_uUSD_z1Vm4Hov2n3c"> </td> <td> </td></tr> <tr style="vertical-align: bottom"> <td style="padding-left: 3pt; text-align: left"> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td style="font-weight: bold"> </td> <td colspan="2" style="font-weight: bold; text-align: right">Average</td><td style="font-weight: bold"> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td style="font-weight: bold"> </td> <td colspan="6" style="border-bottom: rgb(124,189,63) 2px solid; font-weight: bold; text-align: center">Value of Initial Fixed $100 Investment Based On:</td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td><td> </td> <td colspan="2" style="text-align: right"> </td><td> </td></tr> <tr style="vertical-align: bottom"> <td style="border-bottom: rgb(124,189,63) 2px solid; font-weight: bold; padding-left: 3pt; text-align: left">Year</td><td style="border-bottom: rgb(124,189,63) 2px solid; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Summary Compensation Table Total for PEO(1)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Compensation Actually Paid to PEO(2)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Summary Compensation Table Total for Non-PEO NEOs(3)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Average Compensation Actually Paid to Non-PEO NEOs(4)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Total Shareholder Return(5)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Peer Group Total Shareholder Return(6)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Net Income (Loss) (in thousands)(7)</td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; white-space: nowrap; font-weight: bold; text-align: right">Revenue (in thousands)(8)</td><td style="border-bottom: rgb(124,189,63) 2px solid; font-weight: bold"> </td></tr> <tr id="xdx_410_20240101__20241231_zma40lRo4rt1" style="vertical-align: bottom"> <td style="width: 28%; font-weight: bold; text-align: left; padding-left: 3pt">2024</td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right"> $</td><td style="width: 5%; text-align: right">13,717,687</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right"> $</td><td style="width: 5%; text-align: right">8,186,261</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right"> $</td><td style="width: 5%; text-align: right">4,254,959</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right"> $</td><td style="width: 5%; text-align: right">2,790,240</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right">$</td><td style="width: 5%; text-align: right">99</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right">$</td><td style="width: 5%; text-align: right">114</td><td style="width: 1%; text-align: left"> </td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right"> $</td><td style="width: 5%; text-align: right">(569,183)</td><td style="width: 1%; text-align: left"></td><td style="width: 2%"> </td> <td style="width: 1%; text-align: right"> $</td><td style="width: 5%; text-align: right">560,230</td><td style="width: 1%; text-align: left"> </td></tr> <tr id="xdx_41A_20230101__20231231_znvFcBbLKia2" style="vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font-weight: bold; text-align: left; padding-left: 3pt">2023</td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">13,077,993</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">11,293,489</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">4,524,001</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">4,829,669</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">112</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">115</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">(606,639)</td><td style="text-align: left"></td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">434,249</td><td style="text-align: left"> </td></tr> <tr id="xdx_416_20220101__20221231_zWFm9KxPVimb" style="vertical-align: bottom; background-color: White"> <td style="font-weight: bold; text-align: left; padding-left: 3pt">2022</td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">12,140,330</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">3,311,432</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">3,911,773</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">(175,590)</td><td style="text-align: left"></td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">108</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">111</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">(707,421)</td><td style="text-align: left"></td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">363,329</td><td style="text-align: left"> </td></tr> <tr id="xdx_417_20210101__20211231_zm2NFzf4Xtp7" style="vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font-weight: bold; text-align: left; padding-left: 3pt">2021</td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">9,522,738</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">(2,152,804)</td><td style="text-align: left"></td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">3,314,256</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">(1,211,638)</td><td style="text-align: left"></td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">197</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">125</td><td style="text-align: left"> </td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">(454,025)</td><td style="text-align: left"></td><td> </td> <td style="text-align: right">$</td><td style="text-align: right">351,406</td><td style="text-align: left"> </td></tr> <tr id="xdx_413_20200101__20201231_zMPdDyKya0X3" style="vertical-align: bottom; background-color: White"> <td style="border-bottom: rgb(124,189,63) 2px solid; font-weight: bold; text-align: left; padding-left: 3pt">2020</td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">5,144,220</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">22,726,743</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">2,706,102</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">8,015,000</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">324</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">126</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">(186,566)</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"></td><td style="border-bottom: rgb(124,189,63) 2px solid"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">$</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: right">271,030</td><td style="border-bottom: rgb(124,189,63) 2px solid; text-align: left"> </td></tr> </table> 13717687 8186261 4254959 2790240 99 114

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434249000 12140330 3311432 3911773 -175590 108 111

-707421000

363329000 9522738 -2152804 3314256 -1211638 197 125

-454025000

351406000 5144220 22726743 2706102 8015000 324 126

-186566000

271030000 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-bottom: 3pt">(1)</td> <td style="text-align: justify; padding-bottom: 3pt">The dollar amounts reported are the amounts in the “Total” column of the Summary Compensation Table in each applicable year for Dr. Kakkis, who served as our Chief Executive Officer during 2020, 2021, 2022, 2023 and 2024.</td></tr></table> Dr. Kakkis Dr. Kakkis Dr. Kakkis Dr. Kakkis Dr. Kakkis <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-bottom: 3pt">(2)</td> <td style="text-align: justify">The dollar amounts reported represent the amount of CAP, as computed in accordance with SEC rules. The dollar amounts do not reflect the actual amount of compensation earned by or paid during the applicable year. In accordance with SEC rules, the following adjustments were made to total compensation to determine the CAP:</td></tr> </table> <table cellpadding="0" cellspacing="0" id="xdx_30A_z4d9zE3dQf66" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: 8pt Arial, Helvetica, Sans-Serif; padding-left: 3pt">Compensation Actually Paid to PEO</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2024</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2023</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2022</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2021</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2020</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 18pt; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Summary Compensation Table Total</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_986_eecd--PeoTotalCompAmt_c20240101__20241231_zGGjXgnhwPqi" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">13,717,687</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_98C_eecd--PeoTotalCompAmt_c20230101__20231231_zXp7B2YBKBH2" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">13,077,993</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_985_eecd--PeoTotalCompAmt_c20220101__20221231_zWEVlMpQ8yfl" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">12,140,330</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_984_eecd--PeoTotalCompAmt_c20210101__20211231_zZYo0rx9Si4k" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">9,522,738</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_983_eecd--PeoTotalCompAmt_c20200101__20201231_zqckfngkkZhk" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">5,144,220</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Less, value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_982_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zeeyFngVOhy7" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(12,090,111)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98F_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_ztTPJQKyV7te" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(11,618,444)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98A_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_z8F7w1lOdTG6" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(10,773,976)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_989_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zeYgyoCUFOv7" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(8,246,092)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_980_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zzqUYP5WUej6" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(3,709,589)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"></td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: White"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Plus, year end fair value of outstanding and unvested equity awards granted during the year</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_986_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zR62sHapTJN3" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">8,562,675</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98B_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_z8tWPgC8wvVa" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">11,288,072</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_983_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_z831GhIKnE51" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(6,264,762)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_987_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zRSuInN7x7g" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">4,152,033</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98B_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zDv01L8hBYN6" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">10,163,438</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Plus (less), change in fair value from prior year end to current year end of outstanding and unvested equity awards granted in prior years</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_984_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_z9S5OSqXkYQd" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(2,033,745)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_983_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zeef3hyg3N6f" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(1,167,400)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_981_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zs66RiJvr3c3" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(2,934,552)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98F_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zpqQFXef9nYa" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(5,753,632)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_984_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zf14sPYyFcL6" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">9,346,926</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: White"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Plus (less), change in fair value from prior year end to vesting date of equity awards granted in prior years that vested in the year</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_981_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_zaSr4Y45x79e" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">29,755</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_981_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_zMQOVIyAuRpj" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(286,732)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98E_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_znplFWbUw9Nd" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(1,385,132)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_982_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_zq9CtCHVZvbi" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(1,827,851)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_987_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_zjhI9BR0yMtf" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">1,781,748</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Less, prior year-end fair value of any equity awards that failed to meet vesting conditions in the year</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_98E_eecd--AdjToCompAmt_d0_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zFkRxgz52kIh" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98D_eecd--AdjToCompAmt_d0_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zeuS6ymNkeh7" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_980_eecd--AdjToCompAmt_d0_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zcWlkCEp9Sll" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98F_eecd--AdjToCompAmt_d0_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zXXpcyQiFnoc" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_982_eecd--AdjToCompAmt_d0_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--PeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zYGwuw8PuHh4" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: White"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: 8pt Arial, Helvetica, Sans-Serif; text-align: left; padding-left: 3pt">Compensation Actually Paid to Dr. Kakkis</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_983_eecd--PeoActuallyPaidCompAmt_c20240101__20241231_zlgFeryXyCg1" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">8,186,261</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_983_eecd--PeoActuallyPaidCompAmt_c20230101__20231231_z0Rrti5GvYRl" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">11,293,489</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_986_eecd--PeoActuallyPaidCompAmt_c20220101__20221231_zQEI753Fintl" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">3,311,432</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_98F_eecd--PeoActuallyPaidCompAmt_c20210101__20211231_zOx1V0NdQz34" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(2,152,804)</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_98B_eecd--PeoActuallyPaidCompAmt_c20200101__20201231_zAGVAi8zxN5" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">22,726,743</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> </table> 13717687 13077993 12140330 9522738 5144220 -12090111 -11618444 -10773976 -8246092 -3709589 8562675 11288072 -6264762 4152033 10163438 -2033745 -1167400 -2934552 -5753632 9346926 29755 -286732 -1385132 -1827851 1781748 0 0 0 0 0 8186261 11293489 3311432 -2152804 22726743 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-bottom: 3pt">(4)</td> <td style="text-align: justify">The dollar amounts reported represent the average amount of CAP to the NEOs as a group (excluding our CEO), as computed in accordance with SEC rules. The dollar amounts do not reflect the actual average amount of compensation earned by or paid to the NEOs as a group (excluding our CEO) during the applicable year. In accordance with the SEC rules, the following adjustments were made to average total compensation for the NEOs as a group (excluding our CEO) for each year to determine the compensation actually paid, using the same methodology described above in Note 2:</td></tr> </table> <div> <table cellpadding="0" cellspacing="0" id="xdx_30D_zSoUo3HUvHOi" style="font: 8pt Arial, Helvetica, Sans-Serif; border-collapse: collapse; width: 100%" summary="xdx: Disclosure - Pay vs Performance Disclosure"> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: 8pt Arial, Helvetica, Sans-Serif">Compensation Actually Paid to Non-PEO NEOs</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2024</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2023</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2022</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2021</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td colspan="2" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right">2020</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 18pt; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Summary Compensation Table Total</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_984_eecd--NonPeoNeoAvgTotalCompAmt_c20240101__20241231_zIQmnO16HvAe" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">4,254,959</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_983_eecd--NonPeoNeoAvgTotalCompAmt_c20230101__20231231_zRdZrWsE5dQ5" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">4,524,001</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_98A_eecd--NonPeoNeoAvgTotalCompAmt_c20220101__20221231_zSgOEj5L40Ga" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">3,911,773</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_98D_eecd--NonPeoNeoAvgTotalCompAmt_c20210101__20211231_z2dzLesEF4kd" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">3,314,256</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left">$</td><td id="xdx_986_eecd--NonPeoNeoAvgTotalCompAmt_c20200101__20201231_zPWhPitOR6df" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 8%; text-align: right">2,706,102</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; width: 1%; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Less, value of “Stock Awards” and “Option Awards” reported in Summary Compensation Table</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_988_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zqVHlprDy8s6" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(3,293,798)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_989_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zK3ZySHnIori" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(3,831,408)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_981_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zSzGxmD1Mz1k" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(3,130,468)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_982_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zRiBTpqIsNYc" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(2,519,639)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98C_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessValueOfStockAwardsAndOptionAwardsReportedInSummaryCompensationTableMember_zoVfMnUsGTg1" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(2,027,088)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"></td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: White"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Plus, year end fair value of outstanding and unvested equity awards granted during the year</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_983_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zLhVny0sa4K7" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">2,412,702</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98A_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zCzzoNZT7ZSk" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">4,476,201</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98E_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zQIyVCILbam9" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">1,264,910</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_982_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zK0L2GUd5oHa" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">1,268,695</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_988_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusYearEndFairValueOfOutstandingAndUnvestedEquityAwardsGrantedDuringTheYearMember_zUrEtHjdUfje" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">4,150,071</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Plus (less), change in fair value from prior year end to current year end of outstanding and unvested equity awards granted in prior years</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_988_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zwqejKWgeZvf" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(607,133)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98C_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zPpLMMrLWfV3" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(237,537)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98A_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_z598DDJqHmHk" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(784,234)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_985_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zBhhrfhQAjO8" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(2,359,539)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_981_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToCurrentYearEndOfOutstandingAndUnvestedEquityAwardsGrantedInPriorYearsMember_zlJohXMHdSn" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">2,748,610</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: White"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Plus (less), change in fair value from prior year end to vesting date of equity awards granted in prior years that vested in the year</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_985_eecd--AdjToCompAmt_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_z5prV2HNnUid" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">23,510</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98C_eecd--AdjToCompAmt_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_zG97tsCJeG1i" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(101,588)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98C_eecd--AdjToCompAmt_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_z8aZgkGc2ux4" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(573,020)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98B_eecd--AdjToCompAmt_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_z0tW9aVkWsef" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(915,411)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_982_eecd--AdjToCompAmt_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--PlusLessChangeInFairValueFromPriorYearEndToVestingDateOfEquityAwardsGrantedInPriorYearsThatVestedInTheYearMember_zuAiDIapZIm4" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">437,305</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: rgb(240,247,231)"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Less, prior year-end fair value of any equity awards that failed to meet vesting conditions in the year</td><td style="font: 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td><td id="xdx_98C_eecd--AdjToCompAmt_d0_c20240101__20241231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zFxmYxoUJ5Zd" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98B_eecd--AdjToCompAmt_d0_c20230101__20231231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_z5znTwg6jxAc" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_986_eecd--AdjToCompAmt_d0_c20220101__20221231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_z3rsEE4EtkYk" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(864,551)</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_988_eecd--AdjToCompAmt_d0_c20210101__20211231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_z1HMQ6Zrkxfk" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td id="xdx_98A_eecd--AdjToCompAmt_d0_c20200101__20201231__ecd--ExecutiveCategoryAxis__ecd--NonPeoNeoMember__ecd--AdjToCompAxis__custom--LessPriorYearendFairValueOfAnyEquityAwardsThatFailedToMeetVestingConditionsInTheYearMember_zMYK4DBzDCV5" style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">—</td><td style="font: 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> <tr style="font: 8pt Arial, Helvetica, Sans-Serif; vertical-align: bottom; background-color: White"> <td style="font: 8pt Arial, Helvetica, Sans-Serif; background-color: White"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: 8pt Arial, Helvetica, Sans-Serif; text-align: left">Compensation Actually Paid to Non-PEO NEOs</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_98D_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20240101__20241231_zzqfBopr8bne" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">2,790,240</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_98F_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20230101__20231231_zXtxvR3QHXQ" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">4,829,669</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_984_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20220101__20221231_zApZIxSD3wTf" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(175,590)</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_98B_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20210101__20211231_zG7g12xnBjob" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">(1,211,638)</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"></td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle"> </td> <td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">$</td><td id="xdx_984_eecd--NonPeoNeoAvgCompActuallyPaidAmt_c20200101__20201231_zK56WO9l87p7" style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: right; vertical-align: middle">8,015,000</td><td style="border-bottom: rgb(124,189,63) 2px solid; font: bold 8pt Arial, Helvetica, Sans-Serif; text-align: left"> </td></tr> </table> </div> 4254959 4524001 3911773 3314256 2706102 -3293798 -3831408 -3130468 -2519639 -2027088 2412702 4476201 1264910 1268695 4150071 -607133 -237537 -784234 -2359539 2748610 23510 -101588 -573020 -915411 437305 0 0 -864551 0 0 2790240 4829669 -175590 -1211638 8015000 <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-bottom: 3pt">(6)</td> <td style="text-align: justify; padding-bottom: 3pt">Represents the weighted peer group TSR, weighted according to the respective companies’ stock market capitalization at the beginning of each period for which a return is indicated. The peer group used for this purpose is the following published industry index: Nasdaq Biotechnology Index.</td></tr> </table> <table cellpadding="0" cellspacing="0" style="font: 8pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 18pt; padding-bottom: 3pt">(8)</td> <td style="text-align: justify">The dollar amounts reported represent the amount of revenue calculated in accordance with GAAP reflected in the Company’s audited financial statements for the applicable year.</td></tr> </table> revenue Performance Measures As described in greater detail in “Executive Compensation – Compensation Discussion and Analysis,” the Company’s executive compensation program reflects a variable pay-for-performance philosophy. The metrics that the Company uses for both our long-term and short-term incentive awards are selected based on an objective of incentivizing our NEOs to increase the value of our enterprise for our stockholders. The most important performance measures used by the Company to link executive compensation actually paid to the Company’s NEOs, for the most recently completed fiscal year, to the Company’s performance are as follows: <table cellpadding="0" cellspacing="0" style="font: 9pt Arial, Helvetica, Sans-Serif; width: 100%; border-collapse: collapse"> <tr style="vertical-align: top"> <td style="width: 10pt; padding-bottom: 5pt">•</td> <td id="xdx_98A_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__1_zmto8aWNRQO2" style="padding-bottom: 5pt">Total Revenue</td></tr> <tr style="vertical-align: top"> <td style="padding-bottom: 5pt">•</td> <td id="xdx_98A_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__2_zyxaM25yJO3f" style="padding-bottom: 5pt">Relative Total Stockholder Return</td></tr> <tr style="vertical-align: top"> <td style="padding-bottom: 5pt">•</td> <td id="xdx_984_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__3_zIz37IUmUDb7" style="padding-bottom: 5pt">Net Cash Used in Operations</td></tr> <tr style="vertical-align: top"> <td>•</td> <td id="xdx_989_eecd--MeasureName_c20240101__20241231__ecd--MeasureAxis__4_ztrDTDtS43wk">Clinical Development of Product Candidates</td></tr> </table> Total Revenue Relative Total Stockholder Return Net Cash Used in Operations Clinical Development of Product Candidates <img alt="" src="lrare2025_def14ax70x1.jpg" style="width: 527px"/> <img alt="" src="lrare2025_def14ax70x2.jpg" style="width: 527px"/> <img alt="" src="lrare2025_def14ax70x3.jpg" style="width: 527px"/>