Entity Address, City or Town
Entity Address, City or Town
Upfornt cash payment paid.
Upfornt cash payment paid
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Effective Tax Rate of Provision for Income Taxes from Federal Statutory Rate
Fair Value Disclosures [Abstract]
Earnings Per Share [Abstract]
Fair Value, Inputs, Level 1 [Member]
Level 1
Schedule of Accrued Liabilities [Table Text Block]
Accrued Liabilities
2025
Finance Lease, Liability, to be Paid, Year Three
Development and transition costs
Development And Transition Costs
Development And Transition Costs
Domestic Tax Authority [Member]
Federal
Profit share revenue and royalties.
Profit Share Revenue And Royalties [Member]
Profit Share Revenue
Research and Development Expense, Policy [Policy Text Block]
Research and Development
Net Cash Provided by (Used in) Financing Activities [Abstract]
Financing activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate
Weighted-Average Remaining Contractual Term,Outstanding at June 30, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Outstanding, Weighted Average Remaining Contractual Terms
Intangible assets - Gross carrying amount
Intangible Assets, Gross (Excluding Goodwill)
Intangible Assets, Gross (Excluding Goodwill), Total
License Agreement Terms [Member]
License Agreement
Amendment Flag
Amendment Flag
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Total fair value of shares vested
Capital Expenditures Incurred but Not yet Paid
Costs of property and equipment included in accounts payable, accrued, and other liabilities
Depreciation excluding intangible amortization.
Depreciation Excluding Intangible Amortization
Depreciation expense
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Total estimated fair value of options vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized
Share of common stock authorized for future issuance
Intangible assets - Accumulated Amortization
Intangible assets - Accumulated amortization
Finite-Lived Intangible Assets, Accumulated Amortization
Cost of Sales [Member]
Cost of sales
Schedule of activity within liability for sale of future royalties
Schedule Of Activity Within Liability For Sale Of Future Royalties [Table Text Block]
Schedule of activity within liability for sale of future royalties.
Goodwill
Goodwill
Goodwill, Total
Goodwill, Beginning Balance
Goodwill, Ending Balance
License agreement.
License Agreement [Member]
License Agreement
Operating Lease, Right-of-Use Asset
Right-of-use assets
Right-to-use lease asset
Other Commitments [Axis]
Other Commitments
Fair value of sale of shares.
Fair Value Of Sale Of Shares
Common stock, Sale of shares
Increase decrease in contract liabilities.
Increase Decrease In Contract Liabilities
Contract liabilities, net
Proceeds from Sale of Debt Securities, Available-for-Sale
Proceeds from sale of marketable debt securities
Common stock warrants expiring on two thousand twenty.
Common Stock Warrants Expiring On Two Thousand Twenty [Member]
Common Stock Warrants Expiring on 2020
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: Amount representing interest
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block]
Goodwill
Additional at-the-market sales agreement.
Additional At The Market Sales Agreement [Member]
Additional ATM Sales Agreement
Statement [Table]
Statement [Table]
Lease liabilities, non-current
Operating Lease, Liability, Noncurrent
2023
Finance Lease, Liability, to be Paid, Year One
Lessee Disclosure [Abstract]
Finance Lease, Interest Expense
Interest expense
Operating Lease, Payments
Cash paid for measurement of operating lease liabilities
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Business Acquisition [Axis]
Business Acquisition
Auditor Firm ID
Weighted- Average Exercise Price,Outstanding December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Outstanding, Weighted-Average Grant Date Fair Value, Unvested, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Weighted-Average Grant Date Fair Value, vested
Acquisition
Business Combination Disclosure [Text Block]
Time deposits.
Time Deposits [Member]
Time Deposits
Income Tax Authority [Domain]
Income Tax Authority
Deferred Tax Assets, Tax Credit Carryforwards
Tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Total
Product and Service [Axis]
Product and Service
Employee Stock [Member]
Employee Stock Purchase Plan
Operating and finance lease liability payments due.
Operating And Finance Lease Liability Payments Due
Total future lease payments
Commitments and contingencies disclosure.
Commitments And Contingencies Disclosure [Line Items]
Commitments And Contingencies Disclosure [Line Items]
Two thousand eleven equity incentive plan.
Two Thousand Eleven Equity Incentive Plan [Member]
2011 Equity Incentive Plan
Intangible assets - Weighted Average Life
Finite-Lived Intangible Asset, Useful Life
Employee-related Liabilities, Current
Payroll and related expenses
Employee-related Liabilities, Current, Total
Lessee, Operating Leases [Text Block]
Leases
Share-Based Payment Arrangement, Option [Member]
Employee Stock Option
Stock Options
Operating Lease, Weighted Average Remaining Lease Term
Operating lease weighted average remaining lease term
Operating and finance lease liability noncurrent.
Operating And Finance Lease Liability Noncurrent
Lease liabilities
Non-current lease liability
Liabilities and Equity
Total liabilities and stockholders’ equity
Inventory, Policy [Policy Text Block]
Inventory
Plan Name [Domain]
Plan Name
Equity Method Investments [Policy Text Block]
Equity Investments
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Vested
Aggregate intrinsic value
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Fair Value Adjustment of Warrants
Allocated fair value of warrant
International
Deferred Foreign Income Tax Expense (Benefit)
University of Pennsylvania school of medicine.
University Of Pennsylvania School Of Medicine [Member]
University of Pennsylvania School of Medicine (Penn)
Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax
Foreign currency translation adjustments
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Income Statement [Abstract]
Option and license agreement.
Option And License Agreement [Member]
Option and License Agreement
Contract liabilities noncurrent.
Contract Liabilities Noncurrent
Contract liabilities
Investments in Arcturus and solid common stock.
Investments In Arcturus And Solid Common Stock [Member]
Investments in Arcturus and Solid Common Stock
Finance Lease, Weighted Average Remaining Lease Term
Financing lease weighted average remaining lease term
Non-cash interest expense
Non Cash Interest Expense On Liability For Sale Of Future Royalties And Capitalized To Property Plant And Equipment
Non Cash interest expense on liability for sale of future royalties and capitalized to property plant and equipment.
Estimated reimbursement of delivering license and technology services.
Estimated Reimbursement Of Delivering License And Technology Services
Estimated reimbursement of delivering license and technology services
Finance Lease, Liability, Current
Less: Lease liabilities, current
Sale of Stock [Domain]
Sale of Stock
Liabilities, Current
Total current liabilities
Issuance of common stock upon exercise of warrants and under equity plan awards, net of tax, shares.
Issuance Of Common Stock Upon Exercise Of Warrants And Under Equity Plan Awards Net Of Tax Shares
Issuance of common stock upon exercise of warrants and under equity plan awards, net of tax, shares
Percentage of gross accounts receivable balance.
Percentage Of Gross Accounts Receivable Balance
Percentage of gross accounts receivable balance
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Nondeductible permanent items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
2025
Lessee, Operating Lease, Liability, to be Paid, Year Three
Business Acquisition, Acquiree [Domain]
Business Acquisition, Acquiree
Share based compensation arrangement by share based payment award shares available for grant beginning date.
Share Based Compensation Arrangement By Share Based Payment Award Shares Available For Grant Beginning Date
Automatic increases in shares available for grant effective date
Accounts Receivable, Allowance for Credit Loss
Allowance for doubtful accounts
Accounts Receivable, Allowance for Credit Loss, Beginning Balance
Accounts Receivable, Allowance for Credit Loss, Ending Balance
Income Tax, Policy [Policy Text Block]
Income Taxes
Option extension payment
Option Extension Payment
Option extension payment.
2024
Operating and finance lease liability payments due year two.
Operating And Finance Lease Liability Payments Due Year Two
Schedule of share based payment award stock options and employee stock purchase plan valuation assumptions.
Schedule Of Share Based Payment Award Stock Options And Employee Stock Purchase Plan Valuation Assumptions Table [Text Block]
Fair Value of Stock Option Awards Granted Estimated Using Black-Scholes Option-Pricing Model
Collaboration and license.
Collaboration And License [Member]
Collaboration and License
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Deferred Tax Liabilities, Net
Net deferred tax liabilities
Deferred Tax Liabilities, Net, Total
Contingent milestone payment.
Contingent Milestone Payment
Contingent milestone payment
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
2026
Operating and finance lease liability payments due year four.
Operating And Finance Lease Liability Payments Due Year Four
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Components of Company's Income Tax Provision
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease weighted average discount rate
State and Local Income Tax Expense (Benefit), Continuing Operations
State
State and Local Income Tax Expense (Benefit), Continuing Operations, Total
Commercial Paper, Not Included with Cash and Cash Equivalents [Member]
Commercial Paper
Entity Small Business
Entity Small Business
Collaborative arrangements effective reduction of expense.
Collaborative Arrangements Effective Reduction Of Expense
Total
Number of Reportable Segments
Number of reportable segments
Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]
Intangible Assets
Intangible Assets Disclosure [Text Block]
Intangible Assets, Net
Sales reserves adjustments.
Sales Reserves Adjustments
Adjustments
Investments [Domain]
Investments
2014 Incentive plan.
Two Thousand Fourteen Incentive Plan [Member]
2014 Incentive Plan
Liabilities for sales of future royalties
Deferred tax assets liability related to sale of future royalties.
Deferred Tax Assets Liability Related To Sale Of Future Royalties
Class of warrant or right expiration year.
Class Of Warrant Or Right Expiration Year
Common stock warrants, expiration period
Foreign Income Tax Expense (Benefit), Continuing Operations
International
Foreign Income Tax Expense (Benefit), Continuing Operations, Total
Assets, Current
Total current assets
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Contract with Customer, Contract Asset, Contract Liability, and Receivable [Table Text Block]
Summary of Changes in Contract Assets (Liabilities)
Intangible Assets, Net (Excluding Goodwill) [Abstract]
Licensed option maintenance fee.
Licensed Option Maintenance Fee
Annual maintenance fee for each option exercised
Commercial and development activity reimbursements.
Commercial And Development Activity Reimbursements [Member]
Commercial and Development Activity Reimbursements
Weighted-average shares used to computing net loss per share, basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic
Weighted Average Number of Shares Outstanding, Basic, Total
Exclusive options subject to option exercise period.
Exclusive Options Subject To Option Exercise Period
Business acquisition option exercise period, description
Finance Lease, Liability
Present value of future lease payments
City Area Code
City Area Code
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding
Royalties transaction costs net.
Royalties Transaction Costs Net
Royalties transaction costs net
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Options, Options cancelled
Certificate of deposits and time deposits.
Certificate Of Deposits And Time Deposits [Member]
Certificate of Deposits and Time Deposits
Accumulated Other Comprehensive Loss
Comprehensive Income (Loss) Note [Text Block]
Share-Based Payment Arrangement [Abstract]
Liabilities
Total liabilities
Document Period End Date
Document Period End Date
Asset-Backed Securities [Member]
Asset-backed Securities
Option to purchase additional common stock.
Option To Purchase Additional Common Stock
Option to purchase additional common stock, shares
Additional option to purchase common stock
Schedule of Finite-Lived Intangible Assets [Table]
Schedule Of Finite Lived Intangible Assets [Table]
Construction in Progress [Member]
Construction-in-progress
Receivable related to license agreement current.
Receivable Related To License Agreement Current
Receivable related to Daiichi Sankyo license agreement
Right-of-use assets.
Right Of Use Assets [Member]
Right-of-use Lease Assets
Accrued Liabilities
License agreement accrued liabilities
Accrued Liabilities, Total
weighted-average estimated fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Amortized Cost
Debt Conversion, Converted Instrument, Shares Issued
Debt conversion, converted instrument, shares issued
Remaining business combination consideration transferred1.
Remaining Business Combination Consideration Transferred1
Remaining consideration paid
Issuance of common stock under equity plan awards, net of tax.
Issuance Of Common Stock Under Equity Plan Awards Net Of Tax
Issuance of common stock under equity plan awards, net of tax
2023
Finite-Lived Intangible Asset, Expected Amortization, Year One
Statistical Measurement [Axis]
Statistical Measurement
Effective Income Tax Rate Reconciliation, Percent [Abstract]
Undistributed Earnings of Foreign Subsidiaries
Undistributed earnings of foreign subsidiaries
Commercial milestone payment
Commercial Milestone Payment
Commercial milestone payment.
Royalty agreement termination description.
Royalty Agreement Termination Description
Royalty payment termination description
Granted [Member]
Granted.
Thereafter
Finite-Lived Intangible Asset, Expected Amortization, after Year Five
Related Party [Axis]
Related Party
Non Profit Foundation
Non Profit Foundation [Member]
Non Profit Foundation [Member]
Assets
Total assets
Stockholders equity table.
Stockholders Equity [Table]
Stockholders Equity [Table]
Acquisition of equity investment in common stock.
Acquisition Of Equity Investment In Common Stock
Common stock, Acquisition of equity investment
State and Local Jurisdiction [Member]
State
Net loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Net Income (Loss) Available to Common Stockholders, Basic [Abstract]
Numerator:
Crysvita.
Crysvita [Member]
Crysvita
Lessee operating lease expiry year.
Lessee Operating Lease Expiry Year
Operating lease expiry term
Operating and finance lease liability current.
Operating And Finance Lease Liability Current
Lease liabilities
Current lease liability
Less: Lease liabilities, current
Issuance of common stock in connection with license agreement net of issuance costs shares.
Issuance Of Common Stock In Connection With License Agreement Net Of Issuance Costs Shares
Issuance of common stock in connection with license agreement, net of issuance costs, shares
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Outstanding Shares of Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share
Development milestone.
Development Milestone [Member]
Development Milestones
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Revenue from Contract with Customer, Including Assessed Tax
Revenue from sublicense agreement
Upfront payment for in process research and development expense.
Upfront Payment For In Process Research And Development Expense
Upfront payment for in-process research and development expense
Document Fiscal Period Focus
Document Fiscal Period Focus
Acquisition cost
Acquisition Costs, Period Cost
Common stock warrants expiring on two thousand twenty one.
Common Stock Warrants Expiring On Two Thousand Twenty One [Member]
Common Stock Warrants Expiring on 2021
Restrictions on Cash and Cash Equivalents [Table Text Block]
Summary of Reconciliation of Cash, Cash Equivalents and Restricted Cash
Office Equipment [Member]
Furniture and Office Equipment
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]
Organization and Basis of Presentation
Current state income tax expense
Current Income Tax Expense (Benefit)
Total current tax provision
Increase (Decrease) in Accounts Receivable
Accounts receivable
Stock issued during period value at market offering.
Stock Issued During Period Value At Market Offering
Issuance of common stock in connection with at-the-market offering, net of issuance costs
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance, Total
Preferred stock, par value of $0.001 per share - 25,000,000 shares authorized; nil outstanding as of December 31, 2022 and December 31, 2021
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Stock-based compensation
Finance Lease, Liability, to be Paid, Year Five
2026
Payments for (Proceeds from) Other Investing Activities
Other
Profit loss sharing percentage on commercializing products.
Profit Loss Sharing Percentage On Commercializing Products
Remaining profit or loss share percentage on commercializing products
Deferred Tax Liabilities, Gross [Abstract]
Deferred tax liabilities:
Other Capitalized Property Plant and Equipment [Member]
Other
Investment Income, Interest
Interest income
Counterparty Name [Domain]
Counterparty Name
Operating Lease, Liability
Present value of future lease payments
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Deferred Revenue Disclosure [Abstract]
Short-Term Debt, Type [Axis]
Short-term Debt, Type
Open market sale.
Open Market Sale [Member]
Open Market Sale
Solid And Arcturus
Solid and Arcturus [Member]
Solid and Arcturus.
Investment Owned, at Fair Value, Ending Balance
Investment Owned, at Fair Value, Beginning Balance
Investment Owned, at Fair Value
Investment amount
License and Collaboration Agreement
License And Collaboration Agreement [Member]
License and collaboration agreement.
Statement of Financial Position [Abstract]
Entity File Number
Securities Act File Number
Scenario [Domain]
Scenario
Finance Lease, Liability, to be Paid
Total future lease payments
Statement of Cash Flows [Abstract]
Dojolvi.
Dojolvi [Member]
Dojolvi
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Increase decrease in accounts payable accrued liabilities and other operating liabilities.
Increase Decrease In Accounts Payable Accrued Liabilities And Other Operating Liabilities
Accounts payable, accrued, and other liabilities
Restricted Cash and Cash Equivalents, Current, Statement of Financial Position [Extensible Enumeration]
Restricted Cash and Cash Equivalents, Current, Asset, Statement of Financial Position [Extensible List]
Development costs
Development Costs, Period Cost
Geographical [Domain]
Geographical
Statistical Measurement [Domain]
Statistical Measurement
Statement of Stockholders' Equity [Abstract]
Sale of Stock [Axis]
Sale of Stock
Cost sharing payments line items.
Cost Sharing Payments [Line Items]
Cost Sharing Payments [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Percentage of statutory stock awards
Auditor Location
Legal Entity
Legal Entity [Axis]
Changes to number of shares
Stockholders' Equity Note, Changes in Capital Structure, Subsequent Changes to Number of Common Shares
Lease, Cost [Table Text Block]
Summary of Components of Lease Expense
Subsequent Events [Abstract]
Fair Value Disclosures [Text Block]
Fair Value Measurements
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Net of Forfeitures
Number of Options, Options granted
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures, Total
Liabilities for Sales of Future Royalties [Table]
Liabilities for sales of future royalties.
Collaborative arrangements effective reduction of expense in selling, general and administrative expenses.
Collaborative Arrangements Effective Reduction Of Expense In Selling General And Administrative Expenses
Selling, general and administrative
Weighted Average Remaining Contractual Term (Years), Vested and exercisable - December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Proceeds from Stock Options Exercised
Cash received from exercise of options
Proceeds from Issuance of Common Stock
Proceeds from the issuance of common stock in connection with underwritten public offerings, net
Net proceeds from sale of common stock
2023
Contractual Obligation, to be Paid, Year One
Deferred Income Tax Expense (Benefit)
Total deferred tax provision
Deferred Tax Assets, Tax Credit Carryforwards, Research
Tax credit carryforwards
Deferred Income Tax Liabilities, Net
Deferred tax liabilities
Deferred Income Tax Liabilities, Net, Total
Property, Plant and Equipment [Table Text Block]
Summary of Property, Plant and Equipment, Net
Proceeds from (Payments for) Other Financing Activities
Other
Revenue from Contract with Customer [Text Block]
Revenue
Antidilutive Securities [Axis]
Antidilutive Securities
Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised
Proceeds from the issuance of common stock from exercise of warrants and equity plan awards, net
Proceeds, Issuance of Shares, Share-based Payment Arrangement, Including Option Exercised, Total
Deferred Revenue, Revenue Recognized
Revenue recognized
Preferred Stock, Par or Stated Value Per Share
Preferred stock, par value
Royalty purchase agreement.
Royalty Purchase Agreement [Member]
Royalty Purchase Agreement
Arcturus Therapeutics Holdings Inc
Arcturus research collaboration and license agreement.
Arcturus Research Collaboration And License Agreement [Member]
Arcturus
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Gross Unrealized Gains
2027
Operating and finance lease liability payments due year five.
Operating And Finance Lease Liability Payments Due Year Five
Supplemental Balance Sheet Disclosures [Text Block]
Balance Sheet Components
Premium from stock purchase agreement.
Premium From Stock Purchase Agreement
Premium from stock purchase agreement
Option extension premium.
Option Extension Premium
Option extension Premium
Bayer Health Care LLC.
Bayer Health Care L L C [Member]
Bayer HealthCare LLC
First anniversary.
First Anniversary [Member]
First Anniversary
Subsequent Events [Text Block]
Subsequent Event
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Weighted-average shares used to computing net loss per share, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Finite-Lived Intangible Assets, Major Class Name [Domain]
Finite-Lived Intangible Assets, Major Class Name
Number of shares purchased on exercise of common stock option
Number Of Shares Purchased On Exercise Of Common Stock Option
Number of shares purchased on exercise of common stock option
Employment inducement plan.
Employment Inducement Plan [Member]
Employment Inducement Plan
Sales reserves.
Sales Reserves
Balance of product sales reserve at end of year
Balance of product sales reserve at beginning of year
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Research and Development Arrangement, Contract to Perform for Others, Type
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Total unrecognized compensation cost
Payment from sale of future royalties
Payment From Sale Of Future Royalties
Payment From Sale Of Future Royalties.
Current Fiscal Year End Date
Current Fiscal Year End Date
Investment Type [Axis]
Investment Type
Financial Instruments [Domain]
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents, and restricted cash at end of year
Cash, cash equivalents, and restricted cash at beginning of year
Total cash, cash equivalents, and restricted cash shown in the statements of cash flows
Effective Income Tax Rate Reconciliation, Foreign Income Tax Rate Differential, Percent
Foreign rate differential
Other Assets, Noncurrent
Other assets
Other Assets, Noncurrent, Total
Fair Value, Option, Changes in Fair Value, Gain (Loss)
Common stock, Change in fair value
Transfer of fair value on exercise of options.
Transfer Of Fair Value On Exercise Of Options
Common stock, Transfer of value upon option exercise
Entity Address, Address Line One
Entity Address, Address Line One
Research collaboration and license agreement commercial milestones.
Research Collaboration And License Agreement Commercial Milestones [Member]
Research Collaboration and License Agreement Commercial Milestones
Document Annual Report
Document Annual Report
Outstanding Cash and Cash Equivalents Acquired
Outstanding Cash and Cash Equivalents Acquired
Outstanding cash and cash equivalents acquired
Finite-Lived Intangible Assets by Major Class [Axis]
Finite-Lived Intangible Assets by Major Class
Proceeds from sale of future royalties.
Proceeds From Sale Of Future Royalties
Proceeds from sale of future royalties
Deferred tax asset fixed assets and intangibles.
Deferred Tax Asset Fixed Assets And Intangibles
Fixed assets and intangibles
Manufacturing and services.
Manufacturing And Services [Member]
Manufacturing and Services
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Restricted Cash, Noncurrent
Restricted cash included in other assets
Royalty [Member]
Non-cash Collaboration Royalty Revenue
Income Tax Expense (Benefit)
Total provision for income taxes
Provision for income taxes
Components of Deferred Tax Assets and Liabilities [Abstract]
Mahzi Therapeutics Inc [Member]
Mahzi Therapeutics Inc.
Mahzi Therapeutics, Inc.
Finance Lease, Liability, to be Paid [Abstract]
Financing
Income Tax Disclosure [Text Block]
Income Taxes
Vesting [Axis]
Vesting
Balance Sheet Location [Domain]
Balance Sheet Location
Other Accrued Liabilities, Current
Other
Available for sale securities contractual maturity.
Available For Sale Securities Contractual Maturity
Available-for-sale securities remaining contractual maturities
Payments to Acquire Property, Plant, and Equipment
Purchase of property, plant, and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent
Stock-based compensation
Income Tax Disclosure [Abstract]
Disaggregation of Revenue [Abstract]
Stock Issued During Period, Shares, New Issues
Common stock shares sold
Property plant and equipment useful lives.
Property Plant And Equipment Useful Lives Table [Text Block]
Summary of Useful Lives of Property, Plant and Equipment
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Accruals and reserves
Effective income tax rate reconciliation change in uncertain tax positions.
Effective Income Tax Rate Reconciliation Change In Uncertain Tax Positions
Uncertain tax positions
Saint Louis University
Saint Louis University license agreement.
Saint Louis University License Agreement [Member]
Income taxes disclosure.
Income Taxes Disclosure [Table]
Income Taxes Disclosure [Table]
Research collaboration and license agreement development milestones.
Research Collaboration And License Agreement Development Milestones [Member]
Research Collaboration and License Agreement Development Milestones
Percentage of right to receive royalty payments on net sales
Percentage of right to receive royalty payments on net sales.
Fair Value Hierarchy and NAV [Axis]
Level 2
European Union and Switzerland and Turkey.
European Union And Switzerland And Turkey [Member]
Royalty Revenue in European Territory
Royalty Revenue in European Territory
Payments to Acquire Equity Method Investments
Purchase of equity investments
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Auditor Name
License and technology access agreement.
License And Technology Access Agreement [Member]
License and Technology Access Agreement
Baylor Research Institute
Baylor research institute license agreement.
Baylor Research Institute License Agreement [Member]
Equity [Abstract]
Finance Lease, Liability, to be Paid, Year Four
2025
Contract with Customer, Liability, Revenue Recognized
Revenue recognized
Contractual Obligation Maturity Period
Contractual Obligation Maturity Period
Stock issued during period value secondary issues.
Stock Issued During Period Value Secondary Issues
Issuance of common stock in connection with underwritten public offering, net of issuance costs
Schedule of changes in fair value of equity investment.
Schedule Of Changes In Fair Value Of Equity Investment Table [Text Block]
Schedule of Changes in Fair Value of Equity Investment
Option extension right to acquire subject to description.
Option Extension Right To Acquire Subject To Description
Exercise of option extension, right to acquire condition
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Options cancelled
Research, clinical study, and manufacturing expenses.
Research Clinical Study And Manufacturing Expenses
Research, clinical study, and manufacturing expenses
Operating Income (Loss)
Loss from operations
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares Issued in Period
Common stock shares issued
Lessee, Operating Lease, Option to Extend
Operating lease extension details
Related Party [Domain]
Related Party
Finance Lease, Liability, to be Paid, after Year Five
Thereafter
Acquisition, net of cash acquired
Acquisition, net of cash acquired
Payments to Acquire Businesses, Net of Cash Acquired
Payments to Acquire Businesses, Net of Cash Acquired, Total
Scenario [Axis]
Scenario
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Acquisition of investment in common stock.
Acquisition Of Investment In Common Stock
Common stock, Acquisition of investment in securities
Royalty agreement termination threshold amount.
Royalty Agreement Termination Threshold Amount
Royalty agreement termination threshold amount
Purchase price of shares purchased on exercise of common stock option.
Purchase Price Of Shares Purchased On Exercise Of Common Stock Option
Purchase price of shares purchased on exercise of common stock option
Acquired in-process research and development
Research and Development in Process
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Indefinite-Lived Intangible Assets
Business combination recognized intangible assets
Class of Warrant or Right [Domain]
Class of Warrant or Right
Entity Filer Category
Entity Filer Category
Entity Current Reporting Status
Entity Current Reporting Status
Asset Class [Domain]
Asset Class
Inventory, Net
Inventory
Total
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Debt Securities, Available-for-Sale, Current
Marketable debt securities
Debt Securities, Available-for-sale, Current, Total
Research, development and commercialize AAV Gene therapy products agreement.
Research Development And Commercialize A A V Gene Therapy Products Agreement [Member]
Research, Develop and Commercialize AAV Gene Therapy Products
Stockholders' Equity Note Disclosure [Text Block]
Equity
Business Combinations [Abstract]
Total
Finite-Lived Intangible Assets, Net
Finite-Lived Intangible Assets, Net, Ending Balance
Finite-Lived Intangible Assets, Net, Beginning Balance
Stockholders' Equity Attributable to Parent
Ending balance
Beginning balance
Total stockholders’ equity
In Process Research and Development [Member]
IPR&D Assets
In-process Research and Development
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss)
Defined contribution plan.
UnableToMigrateMatchesIfrsDefinedContributionPensionAndOtherPostRetirementPlansDisclosure[Abstract]
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Effect of exchange rate changes on cash
Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Asset Class [Axis]
Asset Class
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Entity Tax Identification Number
Entity Tax Identification Number
Income Statement Location [Axis]
Income Statement Location
Number of shares, cancelled
PSOs cancelled
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Common stock, par value of $0.001 per share - 250,000,000 shares authorized; 70,197,297 and 69,344,998 shares issued and outstanding as of December 31, 2022 and December 31, 2021, respectively
Common Stock, Value, Issued
Common stock investment value
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Mepsevii.
Mepsevii [Member]
Mepsevii
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Adjustment to retained earnings
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Equity Components [Axis]
Equity Components
Income taxes disclosure.
Income Taxes Disclosure [Line Items]
Income Taxes Disclosure [Line Items]
Collaborative arrangements effective reduction of expense in research and development expenses.
Collaborative Arrangements Effective Reduction Of Expense In Research And Development Expenses
Research and development
United States and Canada.
United States And Canada [Member]
Profit Share Territory
Option to sell common stock aggregate offering price.
Option To Sell Common Stock Aggregate Offering Price
Option to sell common stock aggregate offering price
Milestone payments received.
Milestone Payments Received
Milestone payments received
Contract with Customer, Liability
Deferred revenue
Contract with Customer, Liability, Total
Payment for intangible asset
Payment for intangible assets
Payments to Acquire Intangible Assets
Disaggregation of Revenue [Table]
Disaggregation Of Revenue [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Related Party Transaction [Axis]
Schedule of Business Acquisitions, by Acquisition [Table]
Contribution period
Related Party Transaction Contribution Period
Related party transaction contribution period.
Operating Expenses [Abstract]
Operating expenses:
Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax, Beginning Balance
Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax, Ending Balance
Accumulated Other Comprehensive Income (Loss), Foreign Currency Translation Adjustment, Net of Tax
Cumulative foreign currency translation adjustment
Liabilities for Sales of Future Royalties
Liabilities for Sales of Future Royalties [Text Block]
Liabilities for sales of future royalties.
Proceeds from Maturities, Prepayments and Calls of Debt Securities, Available-for-Sale
Proceeds from maturities of marketable debt securities
Revenue [Policy Text Block]
Revenue Recognition
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years)
Share based compensation arrangement by share based payment award shares available for grant ending date.
Share Based Compensation Arrangement By Share Based Payment Award Shares Available For Grant Ending Date
Shares available for grant, ending date
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer
Upfront payment received
Regeneron Pharmaceuticals Inc
Regeneron Pharmaceuticals Inc [Member]
Regeneron pharmaceuticals Inc.
Europe
Europe [Member]
Lessee, Operating Lease, Liability, to be Paid [Abstract]
Operating
GeneTx [Member]
GeneTx [Member]
Debt Securities, Available-for-Sale [Table]
Debt Securities Available For Sale [Table]
Entity Voluntary Filers
Entity Voluntary Filers
Deferred Federal Income Tax Expense (Benefit)
Federal
2025
Operating and finance lease liability payments due year three.
Operating And Finance Lease Liability Payments Due Year Three
Convertible promissory note.
Convertible Promissory Note [Member]
Convertible Promissory Note
Document Transition Report
Document Transition Report
Disclosure of accounting policy for available for sale securities debt securities.
Available For Sale Securities Debt Securities [Policy Text Block]
Marketable Debt Securities
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Components of Company's Loss Before Income Taxes
Schedule of Finite and Indefinite Lived Intangible Assets [Line Items]
Schedule of finite and indefinite lived intangible asset.
Weighted-Average Grant Date Fair Value, granted
Weighted Average Exercise Price,PSOs granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Depreciation, Depletion and Amortization
Depreciation and amortization
Depreciation, Depletion and Amortization, Total
Schedule of Accumulated Other Comprehensive Income (Loss) [Table Text Block]
Schedule of Total Accumulated Other Comprehensive Income (Loss)
Sale of Stock, Price Per Share
Public offering price
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Legally binding minimum lease payments
Legally binding Minimum Lease Payments
Legally-binding minimum lease payments.
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Options exercised
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Foreign
Total accumulated other comprehensive loss
Accumulated other comprehensive loss
Accumulated Other Comprehensive Income (Loss), Net of Tax
Collaborative arrangement and noncollaborative arrangement transactions disclosure.
Collaborative Arrangement And Noncollaborative Arrangement Transactions Disclosure [Text Block]
License and Research Agreements
Accounts Receivable, after Allowance for Credit Loss, Current
Accounts receivable, net
Accounts Receivable, after Allowance for Credit Loss, Current, Total
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Deferred State and Local Income Tax Expense (Benefit)
State
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Operating Lease, Liability, Statement of Financial Position [Extensible List]
Other comprehensive income (loss)
Other Comprehensive Income (Loss), Net of Tax
Other comprehensive income (loss):
Deferred Tax Assets, Equity Method Investments
Basis difference in equity investments
Equity investments noncurrent.
Equity Investments Noncurrent
Equity investments
Net Income (Loss) Attributable to Parent
Net income (loss)
Net loss
Net loss
Finite-Lived Intangible Assets, Remaining Amortization Period
Intangible assets, remaining amortization period
Operating Lease, Liability, Current
Less: Lease liabilities, current
Capitalized research and development costs
Deferred Tax Assets, in Process Research and Development
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Research and development equipment.
Research And Development Equipment [Member]
Research and Development Equipment
OMERS
OMERS [Member]
OMERS [Member]
Collaborative Arrangement, Nature and Purpose
Option and license agreement description
Debt securities in government sponsored entities.
Debt Securities In Government Sponsored Entities [Member]
Debt Securities in Government Sponsored Entities
Schedule of sales-related ccruals and allowances.
Schedule Of Sales Related Accruals And Allowances Table [Text Block]
Schedule of Sales-Related Accruals and Allowances
Deferred Tax Assets, Operating Loss Carryforwards
Loss carryforwards
Deferred tax assets net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Change in fair value of common stock.
Change in Fair Value of Common Stock
Fair value of option to purchase common stock, Change in fair value
Cost Of Sales And Operating Expenses
Cost of sales and operating expenses.
Total operating expenses
Investments in Solid Common Stock
Investment in Solid Common Stock [Member]
Investment in solid common stock member.
Entity Registrant Name
Entity Registrant Name
Cash and Cash Equivalents, at Carrying Value
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Earnings Per Share [Text Block]
Net Loss per Share
Proceeds from issuance of common stock in connection with license agreement.
Proceeds From Issuance Of Common Stock In Connection With License Agreement
Proceeds from the issuance of common stock in connection with the license agreement, net
Proceeds from issuance of common stock in connection with license agreement
Sales
Revenues
Revenues, Total
Statement of Comprehensive Income [Abstract]
upfront payment
upfront payment
upfront payment.
Property, plant and equipment, net
Property, Plant and Equipment, Net
Property, plant, and equipment, net
Property, Plant and Equipment, Net, Beginning Balance
Property, Plant and Equipment, Net, Ending Balance
Finance Lease, Right-of-Use Asset, Amortization
Amortization
Weighted-Average Remaining Contractual Term,Vested and expected to vest December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Award Type [Domain]
Award Type
Statement [Line Items]
Statement [Line Items]
Indefinite-lived Intangible Assets
Indefinite-Lived Intangible Assets [Member]
Program Agreement And Unitholder Option Agreement [Member]
Program agreement and unitholder option agreement.
Program Agreement And Unitholder Option Agreement [Member]
Non cash collaboration royalty revenue.
Non Cash Collaboration Royalty Revenue
Non-cash collaboration royalty revenue
Weighted Average Exercise Price, Vested and expected to vest December 31,2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Title of 12(b) Security
Title of 12(b) Security
Common Stock [Member]
Common Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period
Award expiration period
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Cash, Cash Equivalents, and Restricted Cash
Net Cash Provided by (Used in) Operating Activities [Abstract]
Operating activities:
Equity Component [Domain]
Equity Component
Payments to Acquire Debt Securities, Available-for-Sale
Purchase of marketable debt securities
Two thousand fourteen employee stock purchase plan.
Two Thousand Fourteen Employee Stock Purchase Plan [Member]
2014 Employee Stock Purchase Plan
Total revenues
Collaboration and license revenue
Revenue from Contract with Customer, Excluding Assessed Tax, Total
Revenue
Schedule of collaboration and royalty revenue.
Schedule Of Collaboration And Royalty Revenue Table [Text Block]
Share of Collaboration and Royalty Revenue Related to Crysvita
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Loss before income taxes
Total loss before income taxes
Finance Lease, Liability, Undiscounted Excess Amount
Less: Amount representing interest
Entity Address, State or Province
Entity Address, State or Province
Total
Contractual Obligation
Contractual Obligation, Total
2026
Lessee, Operating Lease, Liability, to be Paid, Year Four
Geographical [Axis]
Geographical
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net (decrease) increase in cash, cash equivalents, and restricted cash
Options to purchase common stock, restricted stock units and performance stock units.
Options To Purchase Common Stock Restricted Stock Units And Performance Stock Units [Member]
Options to Purchase Common Stock, RSUs, and PSUs
Document Type
Document Type
REGENXBIO, incorporated.
R E G E N X B I O Incorporated [Member]
REGENXBIO, Inc.
Development milestone payments.
Development Milestone Payments
Development milestone payments
Entity Shell Company
Entity Shell Company
Class of Warrant or Right, Outstanding
Common stock warrants outstanding
Balance of contract liabilities at end of period, net
Balance of contract liabilities at beginning of period
Contract with customer assets (liability) current.
Contract With Customer Assets Liability Current
Stock issued during period shares at market offering.
Stock Issued During Period Shares At Market Offering
Issuance of common stock in connection with at-the-market offering, net of issuance costs, shares
Stock sold in at-the-market offering
Increase (Decrease) in Inventories
Inventory
Increase (Decrease) in Inventories, Total
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Unrealized loss on securities available-for-sale
AOCI, Debt Securities, Available-for-Sale, Adjustment, after Tax
Unrealized gain on securities available-for-sale
AOCI, Debt Securities, Available-for-sale, Adjustment, after Tax, Total
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
2025
Contractual Obligation, to be Paid, Year Three
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Stock purchased by underwriters pursuant to option granted.
Stock Purchased By Underwriters Pursuant To Option Granted
Shares purchased by underwriters
Corporate Bond Securities [Member]
Corporate Bonds
North America [Member]
North America
Security Exchange Name
Security Exchange Name
DiaCarta Ltd.
Dia Carta Ltd [Member]
Dia Carta Ltd
Revenue from Contract with Customer [Abstract]
Total revenues
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Finance Lease, Liability, Noncurrent
Lease liabilities, non-current
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Net Cash Provided by (Used in) Operating Activities
Net cash used in operating activities
Schedule of Finite and Indefinite Lived Intangible Assets [Table]
Schedule of finite and indefinite lived intangible assets.
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Weighted-average period to recognize cost
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term (Years), Outstanding
Debt Instrument, Interest Rate, Effective Percentage
Effective annual interest rate
Organization and nature of business.
Organization And Nature Of Business [Table]
Organization And Nature Of Business [Table]
Other Comprehensive Income (Loss), Net of Tax [Abstract]
Other comprehensive income (loss):
Payments to Acquire Businesses, Gross
Payments to Acquire Businesses, Gross
Commitments and Contingencies Disclosure [Abstract]
Solid Biosciences, Inc.
Solid Biosciences Inc [Member]
Solid Biosciences, Inc.
Contractual Obligation, Fiscal Year Maturity [Table Text Block]
Summary of Aggregate Payments under Contractually Binding Manufacturing and Service Agreements
Operating Lease, Cost
Operating lease expense
Restricted Stock Units (RSUs) [Member]
Restricted Stock Units
Schedule of Maturities of Lease Liabilities and the Reconciliation of Lease Liabilities
Lessee, Operating Lease, Liability, Maturity [Table Text Block]
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Unrecognized Tax Benefits
Future contingent milestone payments
Future Contigent Milestone Payments
Future contingent milestone payments.
Consolidation, Policy [Policy Text Block]
Basis of Consolidation
2024
Finance Lease, Liability, to be Paid, Year Two
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Summary of Activity Under Stock Units from 2014 Plan
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Activity Under Stock Option Plans Including 2011 Plan and 2014 Plan
Operating and finance lease liability due after year five.
Operating And Finance Lease Liability Due After Year Five
Thereafter
Common Stock, Shares, Outstanding
Beginning balance, shares
Common stock, shares outstanding
Ending balance, shares
Business Acquisition [Line Items]
Inventory, Work in Process, Gross
Work-in-process
Accretion (Amortization) of Discounts and Premiums, Investments
Amortization of premium (discount) on marketable debt securities, net
PCL and HEK293 Platforms
PCL and HEK293 Platforms.
PCL and HEK293 Platforms [Member]
Fair Value, Inputs, Level 2 [Member]
Level 2
Debt Securities, Available-for-sale, Total
Debt Securities, Available-for-Sale
Estimated Fair Value
Net Cash Provided by (Used in) Investing Activities [Abstract]
Investing activities:
Option to sell common stock for cash.
Option To Sell Common Stock For Cash
Option to sell common stock for cash
Operating and finance lease liability from obtaining right of use assets.
Operating And Finance Lease Liability From Obtaining Right Of Use Assets
Acquired lease liabilities arising from obtaining right-of-use assets
Schedule of Expected Amortization of the Intangible Assets
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Additions based on tax positions related to current year
Commitments and contingencies (Notes 9 and 15)
Commitments and Contingencies
Common Stock, Shares, Issued
Common stock, shares issued
Common stock purchased
Common Stock, Shares, Issued, Total
Stock purchase agreement.
Stock Purchase Agreement [Member]
Stock Purchase Agreement
Financing lease.
Financing Lease [Abstract]
Financing:
Current Federal, State and Local, Tax Expense (Benefit) [Abstract]
Current provision for income taxes:
Minimum [Member]
Minimum
Net carrying value of investments.
Net Carrying Value of Investments
Net carrying value of investments
Number of common shares held after split
Stockholders Equity Note Number of Common Shares Held After Split
Stockholders equity note number of common shares held after split.
Restricted Cash, Current
Restricted cash included in prepaid expenses and other current assets
Operating and financing lease.
Operating And Financing Lease [Abstract]
Future Minimum Lease Payments - Operating and Financing Leases
Lessee, Leases [Policy Text Block]
Leases
Weighted- Average Exercise Price,Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Tax Credit Carryforward [Axis]
Tax Credit Carryforward
Kyowa Kirin Collaboration.
Kyowa Kirin Collaboration [Member]
Kyowa Kirin Collaboration
Accrued Liabilities, Current
Accrued liabilities
Total
Stockholders' Equity Attributable to Parent [Abstract]
Stockholders’ equity:
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
State income taxes, net of federal benefit
Schedule of Available-for-Sale Securities [Table]
Schedule Of Available For Sale Securities [Table]
Counterparty Name [Axis]
Counterparty Name
Foreign Currency Transactions and Translations Policy [Policy Text Block]
Foreign Currency
Revenues [Abstract]
Revenues:
Weighted-Average Grant Date Fair Value, cancelled
Weighted Average Exercise Price ,PSOs cancelled
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Regulatory milestone payments.
Regulatory Milestone Payments
Regulatory milestone payments
Non-cash interest expense on liabilities for sales of future royalties capitalized during the year into ending property, plant and equipment
Non-cash interest expense on liability related to the sale of future royalties capitalized into ending property, plant and equipment
Non-cash interest expense on liability related to the sale of future royalties capitalized into ending property, plant and equipment
Product [Member]
Product Sales
Costs of sales related to amortization of intangible asset
Amortization of Intangible Assets
Award Type [Axis]
Award Type
Schedule of Intangible Assets
Schedule of Intangible Assets [Table Text Block]
Schedule of intangible assets.
Other Noncash Income (Expense)
Other
Other Noncash Income (Expense), Total
Contract liabilities current.
Contract Liabilities Current
Contract liabilities
Business Combination, Consideration Transferred
Business acquisition, consideration transferred
Business Combination, Consideration Transferred, Total
Related Party Transaction [Domain]
Deferred Tax Assets, Gross
Gross deferred tax assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Impairment of Long-Lived Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of options exercised
Other income (expense)
Other Nonoperating Income (Expense)
Other Nonoperating Income (Expense), Total
Concentration of credit risk credit losses and other risks and uncertainties.
Concentration Of Credit Risk Credit Losses And Other Risks And Uncertainties Policy [Text Block]
Concentration of Credit Risk, Credit Losses, and Other Risks and Uncertainties
Fit out costs
Fit out Costs
Fit - out costs.
Research and Development Expense
Research and development
Research and development expense related to amortization of assets
Research and Development Expense, Total
Lessee, Operating Lease, Liability, to be Paid
Total future lease payments
Liability for sale of future royalties at end of year
Liability for sale of future royalties at beginning of year
Liability For Sale Of Future Royalties
Liability for sale of future royalties.
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Reductions for tax positions of prior years
Cost of sales.
Cost Of Sales
Cost of sales
Number of common stock purchased.
Number Of Common Stock Purchased
Number of common stock purchased
Liability For Sale Of Future Royalties [Line Items]
Liability For Sale Of Future Royalties [Line Items]
Liability for sale of future royalties.
Entity Central Index Key
Entity Central Index Key
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Valuation allowance increased
Finite-Lived Intangible Assets [Line Items]
Finite Lived Intangible Assets [Line Items]
Restricted Cash and Cash Equivalents, Noncurrent, Statement of Financial Position [Extensible Enumeration]
Restricted Cash and Cash Equivalents, Noncurrent, Asset, Statement of Financial Position [Extensible List]
Accounting Policies [Abstract]
Investments, Debt and Equity Securities [Abstract]
Abeona
Abeona [Member]
Abeona [Member]
Debt Securities, Available-for-Sale [Line Items]
Schedule Of Available For Sale Securities [Line Items]
Disaggregation of Revenue [Line Items]
Disaggregation Of Revenue [Line Items]
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
Operating loss carryforwards expiration year
Eligible future milestone payments.
Eligible Future Milestone Payments
Eligible future milestone payments
Interest Receivable
Interest receivable
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Less accumulated depreciation
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Liabilities for sales of future royalties
Liability related to sale of future royalties.
Liability Related To Sale Of Future Royalties
Liability related to the sale of future royalties at end of year
Liability related to the sale of future royalties at beginning of year
Computer equipment and software.
Computer Equipment And Software [Member]
Computer Equipment and Software
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Abstract]
Finance Lease, Weighted Average Discount Rate, Percent
Financing lease weighted average discount rate
Deferred tax assets stock option.
Deferred Tax Assets Stock Option
Stock options
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Contract with customer liability deductions during period.
Contract With Customer Liability Deductions During Period
Deductions
Other Commitments [Domain]
Other Commitments
Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration
Deferred tax assets operating loss carryforwards subject to expiration
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares available for grant under inducement plan
Share of common stock available for future issuance
Proceeds from sale of equity investment.
Proceeds From Sale Of Equity Investment
Proceeds from sale of equity investments
Share-Based Payment Arrangement [Text Block]
Stock-Based Awards
2024
Contractual Obligation, to be Paid, Year Two
Aggregate Intrinsic Value, Vested and expected to vest - December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Shares vesting monthly after first anniversary.
Shares Vesting Monthly After First Anniversary [Member]
Shares Vesting Monthly After First Anniversary
Sales milestone.
Sales Milestone [Member]
Sales Milestones
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding, Ending Balance
Weighted Average Exercise Price, Outstanding, Beginning Balance
Research and Development Expense
Research and Development Expense [Member]
Research and development
Prepaid Expenses and Other Current Assets [Member]
Prepaid and Other Current Assets
Forecast [Member]
Scenario Forecast
Lease, Cost
Total
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Allocated share based compensation expense net of capitalized inventory cost.
Allocated Share Based Compensation Expense Net Of Capitalized Inventory Cost
Stock-based compensation
Retained Earnings [Member]
Accumulated Deficit
Option to purchase additional common stock value per share.
Option To Purchase Additional Common Stock Value Per Share
Additional option to purchase common stock value per share
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name
Regulatory Approval Milestones
Regulatory approval milestones
Sales reserves, provisions.
Sales Reserves Provisions
Provisions
Money Market Funds [Member]
Money Market Funds
Proceeds from issuance of common stock at market offering.
Proceeds From Issuance Of Common Stock At Market Offering
Proceeds from the issuance of common stock in connection with at-the-market offering, net
Net proceeds from at-the-market offering
Annual fees payable.
Annual Fees Payable
Annual fees payable
Effective Income Tax Rate Reconciliation, Percent
Provision for income taxes
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Operating Lease, Liability, Statement of Financial Position [Extensible List]
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Research and Development Arrangement, Contract to Perform for Others, Type
Property, plant and equipment, gross
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Total
Transaction price of license agreement.
Transaction Price Of License Agreement
Transaction price of license agreement
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Option vesting rights, percentage
Additional Paid in Capital
Additional paid-in capital
Additional Paid in Capital, Total
Additional Paid in Capital, Beginning Balance
Additional Paid in Capital, Ending Balance
Accounts Receivable, after Allowance for Credit Loss
License agreement accounts receivable
Accounts Receivable, after Allowance for Credit Loss, Total
Entity Interactive Data Current
Entity Interactive Data Current
Entity Public Float
Entity Public Float
Vested and expected to vest December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Related Party Transaction
Related Party Transactions Disclosure [Text Block]
Issuance of common stock under equity plan awards, net of tax, shares.
Issuance Of Common Stock Under Equity Plan Awards Net Of Tax Shares
Issuance of common stock under equity plan awards, net of tax, shares
Other Receivables
License agreement other receivables
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosures of non-cash investing and financing information:
Profit loss sharing percentage on net sales.
Profit Loss Sharing Percentage On Net Sales
Profit loss sharing percentage on net sales
Related Party Transactions [Abstract]
2023
Lessee, Operating Lease, Liability, to be Paid, Year One
Organization and nature of business.
Organization And Nature Of Business [Line Items]
Organization And Nature Of Business [Line Items]
Leasehold Improvements [Member]
Leasehold Improvements
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Deferred tax provision:
Local Phone Number
Local Phone Number
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Federal statutory income tax rate
Unrecognized Tax Benefits
Balance at end of year
Balance at beginning of year
Collaboration and license agreement.
Collaboration And License Agreement [Member]
Collaboration and License Agreement
Summary of Financial Assets Measured on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Computation of Basic and Diluted Net Loss per Share
Performance Stock Options [Member]
Performance stock options.
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Stock based awards vesting period
Operating and finance lease liability undiscounted excess amount.
Operating And Finance Lease Liability Undiscounted Excess Amount
Less: Amount representing interest
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Sales reserves payments.
Sales Reserves Payments
Payments
Vested and exercisable December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Number Of Common Stock Held
Number of common stock held.
Number of common stock held
Lessee, Operating Lease, Existence of Option to Extend [true false]
Operating lease, existence of option to extend
Royalty percentage on net sales.
Royalty Percentage On Net Sales
Percentage of royalty on net sales receives
Disaggregation of Revenue [Table Text Block]
Summary of Disaggregation of Total Revenues
Issuance of common stock value in connection with license agreement.
Issuance Of Common Stock Value In Connection With License Agreement
Issuance of common stock in connection with license agreement, net of issuance costs
Other Liabilities, Noncurrent, Total
Other Liabilities, Noncurrent
Other liabilities
Schedule of cost sharing payments.
Schedule Of Cost Sharing Payments Table [Text Block]
Schedule of Cost Sharing Payments
stock split conversion ratio
Stockholders' Equity Note, Stock Split, Conversion Ratio
Japan
JAPAN
Income Statement Location [Domain]
Income Statement Location
Selling, General and Administrative Expenses [Member]
Selling, general and administrative
Property, Plant and Equipment [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Outstanding, Number of Shares, Unvested, Ending Balance
Outstanding, Number of Shares, Unvested, Beginning Balance
Collaboration agreement.
Collaboration Agreement [Member]
Collaboration Agreement
Increase (Decrease) in Prepaid Expense and Other Assets
Prepaid expenses and other assets
Increase (Decrease) in Prepaid Expense and Other Assets, Total
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Share-Based Payment Arrangement, Amount Capitalized
Stock-based compensation capitalized into ending inventory
Underwritten public offering.
Underwritten Public Offering [Member]
Underwritten Public Offering
Dimension Therapeutics Inc.
Dimension Therapeutics Inc [Member]
Dimension
Dimension
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Number of Options, Outstanding, Ending Balance
Number of Options, Outstanding, Beginning Balance
Document Fiscal Year Focus
Document Fiscal Year Focus
Intangible assets - Net Carrying Amount
Intangible Assets, Net (Excluding Goodwill)
Intangible assets, net
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued
Unrecognized tax benefits, income tax penalties and interest accrued
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued, Total
Non-cash interest expense on liabilities for sales of future royalties
Non-cash interest expense on liabilities for sales of future royalties
Non cash interest expense on liability related to sale of future royalties.
Non Cash Interest Expense On Liability Related To Sale Of Future Royalties
Non-cash interest expense
Class of Warrant or Right [Axis]
Class of Warrant or Right
2024
Lessee, Operating Lease, Liability, to be Paid, Year Two
Vesting [Domain]
Vesting
Net loss per share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Tax Credit Carryforward [Table]
Tax Credit Carryforward [Table]
Compensation and Employee Benefit Plans [Text Block]
Defined Contribution Plan
Operating and finance lease liability.
Operating And Finance Lease Liability
Present value of future lease payments
Cost sharing payments abstract.
Cost Sharing Payments [Abstract]
Assets [Abstract]
ASSETS
Investments, Fair Value Disclosure
Common stock, Ending balance
Common stock, Beginning balance
Total fair value
Investments, Fair Value Disclosure, Total
Effective Income Tax Rate Reconciliation, Equity in Earnings (Losses) of Unconsolidated Subsidiary, Percent
Premium on equity issuance
Upfront payments of collaboration.
Upfront Payments of Collaboration
Upfront payments of collaboration
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Share based compensation arrangement by share based payment award minimum percentage of voting rights of all classes of stock.
Share Based Compensation Arrangement By Share Based Payment Award Minimum Percentage Of Voting Rights Of All Classes Of Stock
Minimum percentage of voting rights of all classes of stock
Shares Issued, Price Per Share
Stock price
Debt Instrument, Face Amount
Debt instrument, face amount
Defined Contribution Pension And Other Post Retirement Plan Disclosure [Abstract]
Defined Contribution Pension And Other Post Retirement Plan Disclosure [Abstract]
Revenue share percentage on commercialized products range mid to high.
Revenue Share Percentage On Commercialized Products Range Mid To High
Tiered double-digit revenue share percentage entitled to receive
Orphan drug credits.
Orphan Drug Credits [Member]
Orphan Drug Credits [Member]
Option to purchase common stock value.
Option to Purchase Common Stock Value
Fair value of option to purchase common stock, Beginning balance
Fair value of option to purchase of common stock, Ending balance
Financial Instrument [Axis]
Description of the stock split
Stockholders' Equity Note, Stock Split
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Stock and Warrants Issued During Period, Value, Preferred Stock and Warrants
Warrants issued to purchase preferred stock
Definite-Lived Intangible Asset
Finite lived intangible assets
Finite-Lived Intangible Assets [Member]
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Stock issued during period shares secondary issues.
Stock Issued During Period Shares Secondary Issues
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares
Land [Member]
Land
Transfer of fair value on exercise of options common stock.
Transfer of Fair Value on Exercise of Options Common Stock
Fair value of option to purchase of common stock, Transfer of value upon option exercise
Property, Plant and Equipment, Policy [Policy Text Block]
Property, Plant, and Equipment
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Income Tax Authority [Axis]
Income Tax Authority
Deferred Tax Assets, Net of Valuation Allowance
Total deferred tax assets
Preferred Stock [Member]
Preferred Stock
Assets, Current [Abstract]
Current assets:
2026
Finite-Lived Intangible Asset, Expected Amortization, Year Four
2024
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Class of Warrant or Right, Exercise Price of Warrants or Rights
Common stock warrants, exercise price
Debt Securities, Available-for-Sale, Noncurrent
Marketable debt securities
Research grant agreement.
Research Grant Agreement [Abstract]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Tax Effect of Temporary Differences to Significant Portions of Deferred Tax Assets
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Additions for tax positions of prior years
Stockholders equity line items.
Stockholders Equity [Line Items]
Stockholders Equity [Line Items]
Payables and Accruals [Abstract]
Collaboration and royalty.
Collaboration And Royalty [Member]
Collaboration and Royalty
Employee service share based compensation allocation of recognized period costs capitalized amount including amount expensed to cost of goods sold.
Employee Service Share Based Compensation Allocation Of Recognized Period Costs Capitalized Amount Including Amount Expensed To Cost Of Goods Sold
Stock-based compensation capitalized to inventory
Contract with customer liability additions during period.
Contract With Customer Liability Additions During Period
Additions
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Federal Income Tax Expense (Benefit), Continuing Operations
Federal
Federal Income Tax Expense (Benefit), Continuing Operations, Total
Share-Based Payment Arrangement, Disclosure [Abstract]
Related Party Transaction [Line Items]
Lease, Cost [Abstract]
Entity
Entity [Domain]
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Domestic
Cover [Abstract]
Rare Disease Education And Awareness
Rare Disease Education And Awareness [Member]
Rare Disease Education And Awareness [Member]
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense
Unrecognized tax benefits related to interest or penalties
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total
Product and Service [Domain]
Product and Service
Acquired Finite Lived Intangible Assets Weighted Average Useful Life
Acquired Finite-Lived Intangible Assets, Weighted Average Useful Life
2027
Lessee, Operating Lease, Liability, to be Paid, Year Five
Number of shares, vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Inventory, Finished Goods, Gross
Finished goods
Inventory, Finished Goods, Gross, Total
Tax credit carry forward expiration year.
Tax Credit Carry Forward Expiration Year
Tax credit carryforwards expiration year
Liabilities, Current [Abstract]
Current liabilities:
Sublicense agreement.
Sublicense Agreement [Member]
Sublicense Agreement
Maximum
Maximum [Member]
Common stock warrants.
Common Stock Warrants [Member]
Common Stock Warrants
Contribution amount paid
Related Party Payment of Contribution
Related Party Payment of Contribution
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Unrealized gain (loss) on available-for-sale securities
Mereo
Mereo Bio Pharma3 Limited [Member]
Mereo BioPharma 3 Limited.
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-Based Compensation Expense
Accruals of research and development costs.
Accruals Of Research And Development Costs Policy [Text Block]
Accruals of Research and Development Costs
Commitments and contingencies disclosure.
Commitments And Contingencies Disclosure [Table]
Commitments And Contingencies Disclosure [Table]
Net Cash Provided by (Used in) Investing Activities
Net cash used in investing activities
Furniture and Fixtures [Member]
Furniture and Office Equipment
Equity Securities, FV-NI, Gain (Loss)
Change in fair value of equity investments
Change in fair value of equity investments
Equity Securities, FV-NI, Gain (Loss), Total
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Number of option exercised
Number of Options, Options exercised
Increase (Decrease) in Deferred Liabilities
Deferred tax liabilities
Increase (Decrease) in Deferred Liabilities, Total
Schedule of Inventory, Current [Table Text Block]
Summary of Inventory
Fair Value, Inputs, Level 3 [Member]
Level 3
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Business combination upfront payment.
Business Combination Upfront Payment
Upfront payment for exclusive option to acquisition
Daiichi Sankyo Co., Ltd.
Daiichi Sankyo Co Ltd [Member]
Daiichi Sankyo
Deferred Tax Liabilities, Gross
Gross deferred tax liabilities
Deferred Tax Liabilities, Gross, Total
Additional Milestone Payments
Additional Milestone Payments
Additional milestone payments.
Stock Issued During Period, Value, Stock Options Exercised
Common stock, Purchase price of option exercise
Finance Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]
HeLA PCL platform.
He L A P C L Platform [Member]
HeLA PCL Platform
Licenses Agreement
Licenses Agreement.
Licenses Agreement [Member]
2027
Finite-Lived Intangible Asset, Expected Amortization, Year Five
Cost sharing payments table.
Cost Sharing Payments [Table]
Cost Sharing Payments [Table]
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Other Member
Other member.
Other
Sublicense agreements.
Sublicense Agreements [Member]
Sublicense Agreement
Aggregate Intrinsic Value, Vested and exercisable - December 31, 2022
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Number of disease targets.
Number Of Disease Targets
Number of disease targets
Property, Plant and Equipment, Useful Life
Property plant and equipment useful life
Contribution expenses
Defined Contribution Plan Cost Recognized
Defined Contribution Plan, Cost
Payments made under agreement
Payments Made Under Agreement
Payments made under agreement.
RPI Finance Trust.
R P I Finance Trust [Member]
RPI Finance Trust (RPI)
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Federal tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Deferred Tax Assets, Net [Abstract]
Deferred tax assets:
2025
Finite-Lived Intangible Asset, Expected Amortization, Year Three
Common Stock, Shares Authorized
Common stock, shares authorized
Short-Term Debt, Type [Domain]
Short-term Debt, Type
Payment for purchase of common stock.
Payment For Purchase Of Common Stock
Aggregate purchase price
Trading Symbol
Trading Symbol
Debt Securities, Available-for-Sale [Table Text Block]
Summary of Cash Equivalents and Marketable Debt Securities Classified as Available For Sale Securities
Selling, General and Administrative Expense
Selling, general and administrative
Selling, General and Administrative Expense, Total
Deferred Tax Assets, Other
Other
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent
Other
Effective Income Tax Rate Reconciliation, Other Reconciling Items, Percent, Total
Amount on adjustments for working capital and transaction expenses
Amount on Adjustments for Working Capital and Transaction Expenses
Amount on adjustments for working capital and transaction expenses
Performance Shares [Member]
Performance Stock Units
Equity Method Investments [Member]
Basis Difference in Equity Investments
Balance Sheet Location [Axis]
Balance Sheet Location
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total comprehensive loss
Latin America
Latin America [Member]
2023
Operating and finance lease liability payments due next twelve months.
Operating And Finance Lease Liability Payments Due Next Twelve Months
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Gross Unrealized Losses
Gross Unrealized Losses
Plan Name [Axis]
Plan Name
United states government treasury and agency securities.
U S Government Treasury And Agency Securities [Member]
U.S. Government Treasury and Agency Securities
Schedule of Related Party Transactions, by Related Party [Table]
Contractual payments received.
Contractual Payments Received
Contractual payments received
Schedule of changes in fair value of investment in securities.
Schedule Of Changes In Fair Value Of Investment In Securities Table [Text Block]
Schedule of Changes in Fair Value of Investment in Securities
Business acquisition number of quarters available for extension.
Business Acquisition Number Of Quarters Available For Extension
Extension period available for right to acquisition
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Debt Instrument, Term
Debt instrument maturity period
Issuance of common stock upon exercise of warrants and under equity plan awards, net of tax
Issuance Of Common Stock Upon Exercise Of Warrants And Under Equity Plan Awards Net Of Tax
Issuance of common stock upon exercise of warrants and under equity plan awards, net of tax
Common Stock, Par or Stated Value Per Share
Common stock, par value
Common stock. per share
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Variable Lease, Cost
Variable lease expense
Net proceeds from sale of future royalties in 2022
Proceeds from royalties received financing activities.
Proceeds From Royalties Received Financing Activities
Proceeds from the sale of future royalties, net
Milestone payments paid.
Milestone Payments Paid
Milestone payments paid
GeneTx Biotherapeutics LLC.
Gene Tx Biotherapeutics L L C [Member]
GeneTx Biotherapeutics LLC
Comprehensive Income, Policy [Policy Text Block]
Comprehensive Loss
Commercial milestone payments.
Commercial Milestone Payments
Commercial milestone payments
Number of shares, granted
PSOs granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Two thousand eleven and two thousand fourteen and employment inducement plan.
Two Thousand Eleven and Two Thousand Fourteen and Employment Inducement Plan [Member]
2011 Equity Incentive, 2014 Incentive and Employment Inducement Plan
Finance Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Property, Plant and Equipment, Estimated Useful Lives
Property plant and equipment useful life
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Options granted
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Common stock equivalents excluded from computation of diluted net loss per share
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward [Line Items]