Committee Composition Audit Nominating and Corporate Governance Compensation Research and Development Emil D. Kakkis M.D., Ph.D. Research and Development Lars Ekman M.D., Ph.D Research and Development Deborah Dunsire, M.D. Research and Development Daniel G. Welch Nominating and Corporate Governance Compensation William Aliski Audit Compensation Clay B. Siegall, Ph.D. Compensation Matthew K. Fust Audit Nominating and Corporate Governance Michael Narachi Audit Compensation Shehnaaz Suliman M.D. Nominating and Corporate Governance Research and Development = Chairperson = Member = Chairman of the Board